Everything about Tyrosine Hydroxylase totally explained
,
| Name = Tyrosine hydroxylase
| HGNCid = 11782
| Symbol = TH
| AltSymbols =; TYH
| OMIM = 191290
| ECnumber = 1.14.16.2
| Homologene = 307
| MGIid = 98735
| GeneAtlas_image1 = PBB_GE_TH_208291_s_at_tn.png
| Function =
| Component =
| Process =
| Orthologs =
}}
Tyrosine hydroxylase or
tyrosine 3-monooxygenase is the
enzyme responsible for catalyzing the conversion of the
amino acid L-tyrosine to
dihydroxyphenylalanine (DOPA). DOPA is a precursor for
dopamine which in turn is a precursor for
norepinephrine (noradrenaline) and
epinephrine (adrenaline).
The enzyme, an
oxygenase, is found in the
cytosol of all cells containing
catecholamines. This initial reaction is the
rate limiting step in the production of catecholamines.
The enzyme is highly specific, not accepting
indole derivatives - which is unusual as many other enzymes involved in the production of catecholamines do.
Clinical significance
Tyrosine hydroxylase can be inhibited by the drug α-methyl tyrosine (
Metirosine), however it isn't an effective means of regulating noradrenaline synthesis. This drug is rarely used, but it's useful in treating
pheochromocytoma and also resistant
hypertension.
Tyrosine hydroxylase is an autoantigen in
Autoimmune Polyendocrine Syndrome (APS) type I.
Further Information
Get more info on 'Tyrosine Hydroxylase'.
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